Contaminated Site Clean-Up Information (CLU-IN): Internet Seminar Audio Archives

Since 1998, The Contaminated Site Clean-Up Information (CLU-IN) website has presented Internet Seminars covering a wide variety of technical topics related to hazardous waste characterization, monitoring, and remediation. For each seminar topic, we have selected the highest-quality offering for placement in our archives. Beginning in May 2005, we began offering these archives via podcast, and this feed contains all seminars archived in the last 6 months. For a complete list of seminars archived since 2000 and videos of selected seminars archived since 2012, please visit http://clu-in.org/live/archive/. Our Rehabilitation Act Notice for reasonable accommodation is available at http://clu-in.org/training/accommodation.cfm. CLU-IN was developed by the U.S. Environmental Protection Agency (EPA) but is intended as a forum for all waste remediation stakeholders. For more information and to view upcoming live offerings, please visit http://clu-in.org/live/. For a complete list of RSS feeds available on CLU-IN, please visit http://clu-in.org/rss/about/.

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Audio for "The Interplay Between Environmental Exposures and Infectious Agents: Session III - Co-exposures in the Lung," Nov 7, 2016


The NIEHS Superfund Research Program (SRP) presents the third session in the Risk e-Learning series, The Interplay Between Environmental Exposures and Infectious Agents. The seminar series examines the interactions between environmental exposures and infectious agents in the development of disease. The series will highlight researchers from around the country who are doing innovative research to better understand this relationship between environmental exposures, infectious agents, and immune response. This session series will focus on interactions between environmental exposures and infectious agents in the lung. Steven Kleeberger, Ph.D., a principle investigator in the NIEHS Intramural Research Program, will describe his work to understand the mechanisms of Respiratory Syncytial Virus (RSV) infection and disease severity and how that relates to exposure to environmental insults. His findings may help identify individuals at risk for severe RSV infection. Fenna Sillé, Ph.D., an assistant professor at Johns Hopkins University and former University of California, Berkeley SRP postdoctoral researcher, will discuss how early-life exposure to arsenic permanently changes the immune system and increases infectious disease risk later in life, using Mycobacterium tuberculosis in the lung as the model. Their observations in Chile suggest that arsenic impacts critical processes that occur in early life, such as the developing immune system, thereby contributing to increased mortality risk from cancer, bronchiectasis and tuberculosis (TB) later in life. As part of their studies, they observed metabolic and immunogenic alterations in arsenic exposed macrophages and mice as well as effects on TB pathogenicity in vivo. Together, their data elucidates how arsenic influences infectious disease risk in exposed populations. Stephania Cormier, Ph.D., a professor at the University of Tennessee Health Science Center and Center Director of the Louisiana State University SRP Center, will discuss the relationship between environmentally-persistent free radicals (EPFRs) and severity of respiratory viral infections. Exposure to elevated levels of particulate matter containing EPFRs is associated with increased risk of morbidity and mortality from respiratory tract viral infections in children. She will discuss how early-life exposure to EPFRs elicits active immunosuppressive and demonstrate the role of Tregs and IL10 in enhanced influenza severity. Finally, she will demonstrate that blocking such immune responses can protect against severe disease. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/SRPInterplay3_110716/


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 November 8, 2016  1h53m