System-level biochemical modeling is a necessary and powerful tool for health researchers analyzing biochemical pathways of toxicological relevance. Computational models are valuable in demonstrating both the normal functioning of cellular signaling pathways and the nature and magnitude of perturbations when contaminants are introduced into the system. This podcast give the background, advances, and significance of recent work conducted by Dr. Norbert Kaminski, Program Director of Michigan State University SRP, and his team or researchers.