Since 1998, The Contaminated Site Clean-Up Information (CLU-IN) website has presented Internet Seminars covering a wide variety of technical topics related to hazardous waste characterization, monitoring, and remediation. For each seminar topic, we have selected the highest-quality offering for placement in our archives. Beginning in May 2005, we began offering these archives via podcast, and this feed contains all seminars archived in the last 6 months. For a complete list of seminars archived since 2000 and videos of selected seminars archived since 2012, please visit http://clu-in.org/live/archive/. Our Rehabilitation Act Notice for reasonable accommodation is available at http://clu-in.org/training/accommodation.cfm. CLU-IN was developed by the U.S. Environmental Protection Agency (EPA) but is intended as a forum for all waste remediation stakeholders. For more information and to view upcoming live offerings, please visit http://clu-in.org/live/. For a complete list of RSS feeds available on CLU-IN, please visit http://clu-in.org/rss/about/.
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Audio for "Exposures and Latent Disease Risk: Session IV - Moving Forward," Jun 16, 2020
The NIEHS Superfund Research Program (SRP) is hosting a Risk e-Learning webinar series focused on exposures and latent disease risk. The series features SRP grantees and colleagues who are studying the health effects of exposures when there is a lag between exposure and the onset of disease. In the fourth and final session, presenters will discuss emerging toxicology and modeling methods, as well as needs, to better link exposure to latent disease risk. Stefano Monti, Ph.D., associate professor at Boston University, will provide an overview of the experimental and computational approaches he and his team have developed and applied to model environmental chemicals and to predict their long-term adverse effects from short-term omics assays. In particular, he will present vignettes from two studies, the first aimed at predicting chemical carcinogenicity and genotoxicity, and the second aimed at defining a molecular taxonomy of metabolism-disrupting chemicals. The focus will be on the experimental design and the computational approaches adopted, as well as on some of the challenges and lessons learned. Stephen Ferguson, Ph.D., a scientist in the National Toxicology Program (NTP) Division of the NIEHS, will describe emerging toxicological approach methods (TAMs), which seek to enhance our understanding of human responses to xenobiotic exposures and their translation to human health outcomes. He will discuss progress at NTP towards enhancing the physiological relevance of Tox21 research through qualification of 3D liver screening models paired with informative assay systems (e.g., high throughput transcriptomics) in response to reference human therapeutics and environmental chemicals. Manish Arora, Ph.D., professor at the Icahn School of Medicine at Mount Sinai, will describe his work focused on environmental biodynamics, which focuses on the interplay between the environment and the body. He will discuss rethinking the role of time in environmental health research and will be sharing his work on neurological disorders at different life stages. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/SRPExposures4_061620/