the bioinformatics chat

A podcast about computational biology, bioinformatics, and next generation sequencing.

https://bioinformatics.chat

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episode 48: Machine learning for drug development with Marinka Zitnik


In this episode, Jacob Schreiber interviews Marinka Zitnik about applications of machine learning to drug development. They begin their discussion with an overview of open research questions in the field, including limiting the search space of high-throughput testing methods, designing drugs entirely from scratch, predicting ways that existing drugs can be repurposed, and identifying likely side-effects of combining existing drugs in novel ways. Focusing on the last of these areas, they then discuss one of Marinka’s recent papers, Modeling polypharmacy side effects with graph convolutional networks.

Links:

  • Modeling polypharmacy side effects with graph convolutional networks (Marinka Zitnik, Monica Agrawal, Jure Leskovec)
  • Network Medicine Framework for Identifying Drug Repurposing Opportunities for COVID-19 (Deisy Morselli Gysi, Ítalo Do Valle, Marinka Zitnik, Asher Ameli, Xiao Gan, Onur Varol, Helia Sanchez, Rebecca Marlene Baron, Dina Ghiassian, Joseph Loscalzo, Albert-László Barabási)
  • AI Cures initiative

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 July 29, 2020  1h25m