American Journal of Psychiatry Audio

Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research. This podcast is subject to the Terms of Use at ww.psychiatry.org. The views and opinions expressed in this podcast are those of the individual speakers only and do not necessarily represent the views of the American Psychiatric Association, its officers, trustees, or members. The content of this podcast is provided for general informational purposes only and is not intended as, and shall not be understood or construed as, medical or any other type of professional advice nor does it represent any statement of the standard of care. We strongly recommend that any listener follow the advice of physicians directly involved in their care and contact their local emergency response number for any medical emergency. The information within this podcast is provided as-is and is not guaranteed to be correct, complete, or accurate.

https://ajp.psychiatryonline.org/audio

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August 2020: Hormonal Treatments for Major Depressive Disorder


Executive Editor Michael Roy speaks with Jennifer Dwyer, M.D., Ph.D., and Awais Aftab, M.D., about the physiology of three major endocrine systems and about the evidence for hormone-based interventions in the treatment of major depressive disorder.

Dr. Dwyer is an assistant professor at Yale University, where she is affiliated with the Child Study Center and the Department of Radiology and Biomedical Imaging. Dr. Aftab is a clinical assistant professor in the Department of Psychiatry at Case Western Reserve University. He is also an attending psychiatrist at Northcoast Behavioral HealthCare Hospital.

  • Why are effective treatments for major depressive disorder lacking? [2:22]
  • Why have hormones been implicated in the pathophysiology of major depression? [4:28]
  • Three particular parts of the hormonal system that have been linked to alterations in mood [7:05]
  • The role of the HPA axis in major depression [8:44]
  • The role of the HPT axis in major depression [11:39]
  • The role of the HPG axis in major depression, and differences between men and women [19:42]
  • The efficacy, or drawbacks, of different kinds of hormonal interventions to treat depression [31:15]
  • Overall conclusions as to the utility of hormonal treatments for major depression [39:04]
  • The main messages that researchers, clinicians, and other mental health professionals should take away from the article [40:22]
  • Recommendations for further research in this area [41:32]

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 August 1, 2020  45m