This Week in Virology

TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.


episode 674: In the company of coronaviruses with Lisa Gralinski

Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Lisa Gralinski

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Links for this episode
  • SARS-like bat CoV with potential for human emergence (Nat Med)
  • SARS-CoV susceptibility loci in CC mice (PLoS Genetics)
  • Combination attenuation for SARS-CoV vaccine (J Virol)
  • Orally administered SARS-CoV-2 antiviral (Res Sq)
  • Spike protein induces analgesia (Pain)
  • Letters read on TWiV 674
  • Timestamps by Jolene. Thanks!
Weekly Science Picks

Brianne – The Lonely Pipette Podcast: Mentoring with Harmit Malik
Kathy –  Dr. Boyd the Chemist one and two  GREAT short videos one and two,  How to read an old school thermometer, New Marvel storyline  Wear a Mask parody of Be My Guest
Rich – Clear+Vivid with Alan Alda
Vincent – Immune 36: Aberrant immunity in COVID-19

Listener Pick

Ryan – Dr. Fauci on politicization of pandemic

Intro music is by Ronald Jenkees

Send your virology questions and comments to



 2020-10-22  1h58m