A podcast about computational biology, bioinformatics, and next generation sequencing.
https://bioinformatics.chat
episode 52: How 23andMe finds identical-by-descent segments with William Freyman
In this episode, Will Freyman talks about identity-by-descent (IBD): how it’s used at 23andMe, and how the templated positional Burrows-Wheeler transform can find IBD segments in the presence of genotyping and phasing errors.
Links:
- Fast and robust identity-by-descent inference with the templated positional Burrows-Wheeler transform (William A. Freyman, Kimberly F. McManus, Suyash S. Shringarpure, Ethan M. Jewett, Katarzyna Bryc, the 23andMe Research Team, Adam Auton)
- 23andMe research
If you enjoyed this episode, please consider supporting the podcast on Patreon.