episode 742: De-fusing COVID-19
TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode- TMEM16 inhibitors block SARS-CoV-2 driven syncytium formation (Nature)
- Letters read on TWiV 742
- Timestamps by Jolene. Thanks!
Brianne – COVID-19: a disaster five years in the making
Alan – The Tyranny of Merit
Rich – Racism Makes Me Question Everything. I Got the Vaccine Anyway
Kathy – The Transcontinental Burrito Tunnel
Vincent – Trudy Rey’s YouTube Channel
Jeff – Rebecca Lee Smith on Left Right and Center
Ryan – Perfect Strangers (clip)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv