Getting To Know The Fungus Among Us (In Our Guts)
Your gut microbiome is composed of more than bacteria—a less populous, but still important, resident is fungi. Many people’s lower digestive tract is home to the yeast Candida albicans, the species implicated in vaginal yeast infections and oral thrush. But new research published in the scientific journal Nature this month suggests that Candida in the gut may also be related to severe cases of inflammatory bowel disease, or IBD.
Candida comes in multiple forms: a single-celled, rounded yeast, and a multicellular, branched version, known as the hyphal form. The latter is capable of invading other cells, and is associated with tissue damage, like that of IBD. The research team writes that our immune system reacts to candida by targeting a protein found on that second, invasive state. Conversely, our bodies seem to leave the rounded, yeast form alone.
Better understanding what drives these distinct responses may provide clues to developing a vaccine that could help people with candida-linked health problems. And postdoctoral researcher Kyla Ost tells guest host Roxanne Khamsi that the relationship appears to be mutualistic—that is, the fungi themselves benefit from being managed in this way.
She explains the nuanced relationship she and her colleagues uncovered, and how uncovering more about gut fungi may bring new insights into the relationship between our microbial communities and our health.
COVID And Climate Change Collide At The Olympics
The Tokyo Olympics have been underway for a week, with talented athletes competing at their peak. But this year, it’s hard to watch the Olympics without thinking about two of the biggest science stories of the summer: COVID-19, and the record heat and humidity athletes are facing as part of this year’s games.
Holding the Olympics during a global pandemic is uncharted territory, and keeping the virus out of the games has been a huge logistical challenge. There are more than 11,000 athletes participating in this summer’s games, coming from 206 nations. Factor in the coaches, staff, press, and service workers, and that’s a lot of people to keep healthy.
As if that wasn’t enough, Tokyo is experiencing extreme heat and humidity, consistently reaching 90 degrees Fahrenheit with humidity at about 80%. While the city has always had hot summers, they have gotten worse with climate change. Tokyo’s average annual temperature has risen by more than 5 degrees Fahrenheit since 1900, according to NASA. Athletes have had to take additional measures to keep themselves cool.
To tackle these stories, guest host Roxanne Khamsi talks to sports writer Hannah Keyser, from Yahoo Sports, about the Olympics’ COVID-19 protocols, as well as her experience as a reporter covering the games in Tokyo. Then, Roxanne speaks with Scott Delp, professor of bioengineering at Stanford University and director of the Wu Tsai Human Performance Alliance, about athletic performance and safety.
What’s Shaking Below Mars’ Surface?