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Over 2700 people in England may be affected if health watchdog NICE decide not to approve a "breakthrough" treatment for people with cystic fibrosis for use on the NHS. The drug Orkambi, which costs £104,000 a year per patient, has been shown to improve lung function and respiratory symptoms in people with cystic fibrosis, but NICE said the benefits were modest. Fourteen-year-old Clara Mann, who has cystic fibrosis, and her father Nicholas Mann discuss the benefits the drug has had on her life. (Image: Child with nurse. Credit: SPL)