Pushing The Limits

In this weeks episode we dive into a topic that is close to my heart after watching the pain and suffering my mum went through and the complications and difficulties she has had after falling in her bedroom one day and breaking her hip.   This experience of course led me deep into the research on osteoporosis and in todays video/podcast we cover 

1. What osteoporosis is and what osteopenia is 
2. How is it diagnosed 
3. What drugs are used to to treat it - the good, the bad and the ugly of these
4. What exercises you can do to stave off osteoporosis and reverse bone loss
5. What nutrient deficiencies or diseases can lead to osteoporosis 
6. What supplements can reverse and or slow bone loss
7. The role of different hormones in osteopororsis 
8. The role of nutrition in osteoporosis 
9. What medications can cause osteoporosis 
10. What lifestyle factors can lead to osteoporosis
11. Who is more at risk for osteoporosis.

General info on osteoporosis  Loss of Bone Mass Density
Dexa Scan T-score  -1.0 to -2.5 is Osteopenia
                    T-score  less than -2.5 is Osteoporosis
Bone is 40-50% inorganic component (hydroxyapatite), 10-15% water and 35% organic component(protein).  90% of the organic component is collagen Type 1 and the remaining 10% non-collagenous proteins

• Osteoblasts-formation of bone, secrete alkaline phosphatase to create sites for calcium and phosphate deposition.
• Osteoclasts-bone resorption, secretes acid phosphatase which unfixes the calcium
• Osteocytes are osteoblasts which are responsible for homeostasis of oxygen and mineral levels.

Function: Supports the body, protects the organs, produces blood cells, and stores minerals and fats.

• Collagen, the protein that gives bones a framework for strength and   flexibility
• Calcium-phosphate mineral complexes, that fill in the gaps between the collagen frame work, making bones hard and strong
• Living bone cells that remove and replace weakened sections of bone

KoACT-Calcium collagen chelate
Animal Study-8 weeks
4 groups
No supplement
KoACT-increased bone density by 3.5%
10x KoACT-increased bone strength by 10%
Calcium and Collagen supplement increase bone strength by 1%

Study
39 women
2 groups-12 months Post-menopausal women.
5 g of CC(calcium-collagen chelate) which contains 500 mg of elemental calcium and 200 IU Vitamin D
500 mg of calcium and 200 IU of Vitamin D
The loss of whole body BMD in women taking CC was substantially lower than that of the control group at twelve months

KoACT improves bone synthesis and reduces bone loss

• KoACT counteracts the natural process of bone loss in post-menopausal women
• KoACT improves bone mineral density
• KoACT improves bone mineral density better than calcium in post-menopausal women
• KoACT improves total body bone mineral density significantly better than calcium in just three months
• Biomarkers for bone formation were increased significantly with KoACT
• KoACT improves biomarkers for bone formation, better than calcium.
• KoACT improves bone strength significantly better than calcium in animals

Peak bone mass is around 30 years old. Losing 2-3% a year thereafter. 20% of hip fracture patients will pass away within a year.
1 out of 3 post menopausal women will fracture a bone

Osteoporosis drugs (Bisphosphonate) slows down osteoclast activity. Increase risk of jaw necrosis and atypical femoral fractures.  After 3 years of use the suggest a "Drug Holiday"

Lifestyle:
Lack of physical activity
Excessive exercise
Inflammation
Smoking
Alcohol
Medication
Family history
Vitamin and nutrient deficiency
Gluten

Eliminate excess sugar, cigarette smoke and phosphoric acid-containing soda.
Be sure your intake of calcium and magnesium is in the 700-1000 mg range of each daily.
Other trace minerals, boron, manganese, chromium, copper, zinc, silicon...animal food
Weight bearing activity
Post-menopausal women make consider bioidentical hormone replacement.
Mediterranean diet with increase protein intake.

Vegetarian and vegan diets and risks of total and site-specific fractures increases significantly.

Exercise:
Weight bearing resistance exercise is best
Vibration-10 minutes per day 2-3x per day (check with your medical professional first)
Muscle-vibration 20-50 hz
Exercise inhibits bone loss, frequency matters     clinical research links mentioned in this podcast 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308846/ https://pubmed.ncbi.nlm.nih.gov/9177517/ https://pubmed.ncbi.nlm.nih.gov/9431639/ https://www.ncbi.nlm.nih.gov/books/NBK499863/#:~:text=Wolff's%20Law%20states%20that%20bones,strengthening%20of%20the%20cortical%20layer. https://pubmed.ncbi.nlm.nih.gov/23702931/#:~:text=Menaquinone%2D4%20(MK%2D4,health%20in%20healthy%20postmenopausal%20women.  

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Lisa and team