Contaminated site cleanup and environmental stewardship are costly tasks and continued research and innovation can lower the financial burden to site owners and to the taxpayer. A variety of technologies addressing groundwater contamination emerged and have been implemented. Bioremediation takes advantage of naturally occurring microorganisms that detoxify contaminants and in situ implementation of this approach promises to meet cleanup goals at reasonable costs. While biostimulation and bioaugmentation have been successfully applied at numerous sites, the current approaches should be considered brute-force, and more refined treatment (i.e., precision bioremediation) will result in a similar reduction of contaminant concentrations at substantially lower capital investment and lesser environmental impacts. Progress in understanding of the microbiology contributing to chlorinated solvent detoxification under anoxic conditions serves as an example how investments in fundamental research and translational efforts can advance bioremediation from an empirical practice to an approach with predictable outcomes. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/ISB_031317/