Since 1998, The Contaminated Site Clean-Up Information (CLU-IN) website has presented Internet Seminars covering a wide variety of technical topics related to hazardous waste characterization, monitoring, and remediation. For select seminar topics offered since 2012, we are making complete video recordings available through our archives. This feed contains all video seminars archived in the last 12 months. For a complete list of seminars archived since 2000, please visit http://www.clu-in.org/live/archive/. Our Rehabilitation Act Notice for reasonable accommodation is available at http://www.clu-in.org/training/accommodation.cfm. CLU-IN was developed by the U.S. Environmental Protection Agency (EPA) but is intended as a forum for all waste remediation stakeholders. For more information and to view upcoming live offerings, please visit http://www.clu-in.org/live/. For a complete list of RSS feeds available on CLU-IN, please visit http://www.clu-in.org/rss/about/.
http://www.clu-in.org/live/archive
Adverse Outcome Pathways: Session I - Introduction to the Adverse Outcome Pathway Framework (Oct 11, 2017)
The NIEHS Superfund Research Program (SRP) is hosting a seminar series focused on adverse outcome pathways (AOPs), which are structured ways to represent biological events leading to adverse health effects. In the first session, U.S. Environmental Protection Agency (EPA) staff will provide an introduction and overview of AOPs and discuss the AOP Knowledgebase, which is designed to house descriptions of the biological mechanisms underlying chemical toxicity in a structured manner. The AOP framework was developed as a means for organizing biological and toxicological knowledge concerning the linkages between molecular-level perturbations of biological systems by stressors and the apical hazards (e.g., disease in humans, reduced survival, growth, reproduction in wildlife) that can result. As such, the AOP framework can help support greater use of mechanistic or pathway-based data in risk assessment and regulatory decision-making. Daniel Villeneuve, Ph.D., will introduce the AOP framework, major principles that guide the development and description of AOPs within the AOP-knowledgebase, and will give examples of some prominent applications of AOPs. Stephen Edwards, Ph.D., will discuss the design of the AOP Knowledgebase and how this supports both AOP development and use. It will include the assembly of AOP networks and their importance when using AOPs. It will also consider methods for developing AOP networks in an automated fashion to complement the expert-driven AOP development efforts within the AOP knowledgebase. This webinar is also in support of an upcoming NIEHS/NHLBI Workshop, Understanding the Combined Effects of Environmental Chemical and Non-Chemical Stressors: Atherosclerosis as a Model, which will take place at NIEHS in Research Triangle Park, North Carolina, April 3 - 4, 2018. The goal of this workshop is to identify key biological mechanisms/pathways of the combined effects of chemical and non-chemical stressors associated with atherosclerosis. A critical research area that requires further exploration is the biological mechanisms and effects of exposure to both environmental chemicals (e.g., air pollution, polycyclic aromatic hydrocarbons, metals, pesticides) and non-chemical stressors (e.g., psychosocial, lifestyle, quality of life, poor nutrition, infectious agents, physical stressors) over time and the roles they may play in the development of disease (e.g., cancer, cardiac, metabolic, neurological). This workshop will bring together experts to discuss the state of the science pertaining to underlying biological pathways associated with, when combined, chemical and non-chemical stressors in relation to atherosclerosis. This workshop will use the AOP framework to assist in the discussion of the pathways considered by workshop participants. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/AdvOutPathways1_101117/