Scott Tenner, MD, MPH, FACG, co-author of the American College of Gastroenterology's new Clinical Guideline on the Management of Acute Pancreatitis, published in the September issue of AJG, talks with co-Editor Dr. William Chey about the increasing prevalence of acute pancreatitis; the appropriateness of CT, MR, ERCP, and genetic testing in diagnosis of the disease; and the role of antibiotics, re-feeding, surgical debridement, and lactated ringer's solution versus normal saline in the management of acute pancreatitis.