Drs. Eamonn Quigley and Paul Moayyedi, co-authors of the new ACG Monograph on the management of IBS and CIC, talk with AJG Co-Editor Dr. William D. Chey about the rapidly changing field of IBS and CIC treatments, the new relevance of products such as probiotics and antibiotics in altering the microbiome in IBS patients, recommendations for PEG and newer prosecretory agents in IBS-C and CIC, and the use of drugs such as alosetron and ondansetron for severe IBS-D. (22:44)