AJP-Heart and Circulatory Physiology Podcast

Special Dual Language Podcast in Chinese and English: What fascinating findings are presented on the differences between pressure overload and volume overload induced cardiac hypertrophy? Listen to this intriguing podcast as Professor Jie Liu from Shenzhen University of China interviews the corresponding authors Drs. Yunzeng Zou and Jian Wu from Fudan University of China, and the first author Dr Jieyun You from Tongji University, talking about their work on different phenotypic, functional and molecular adaptations in cardiac hypertrophy under different mechanical stress. The authors utilized a mouse model of pressure overload induced by transverse aortic constriction, and a newly developed mouse model of volume overload induced by aortic regurgitation, to make a comparative study on the differences between the two types of cardiac hypertrophy. What are the prominent differences between the two types of hypertrophy? Which hypertrophy seems more benign? What are the translational implications for personalized therapeutics for cardiac hypertrophy? Listen now and learn more. 

Jieyun You, Jian Wu, Qi Zhang, Yong Ye, Shijun Wang, Jiayuan Huang, Haibo Liu, Xiaoyan Wang, Weijing Zhang, Liping Bu, Jiming Li, Li Lin, Junbo Ge, and Yunzeng Zou Differential cardiac hypertrophy and signaling pathways in pressure versus volume overload Am J Physiol Heart Circ Physiol, published December 1, 2017. DOI: 10.1152/ajpheart.00212.2017