TWiV 351: The dengue code
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome.
Links for this episode- Paula Pitha-Rowe (Balt Sun)
- Novel poxvirus (CID)
- H1N1 and gain-of-function debate (mBio)
- Recoding dengue virus genome (PNAS)
- Attenuation by dinucleotide frequency change (PNAS)
- Codon pair and dinucleotide bias not distinguished (PNAS)
- Codon pair deoptimization artefact of CG/UA change (eLife)
- Can engineering subdue viral vaccine reversion? (Virus Evol)
- Attenuation by a thousand cuts (NEJM)
- Image credit
- Letters read on TWiV 351
Alan - Genetic roulette
Rich - The Huntington
Kathy - Simulated vomiting machine (video)
Dickson - Last Cassini Saturn flyby
Vincent - Decaying Still Life (YouTube)
Ken - Cave meterology (Times, Nature)
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