episode 819: How to stall a copy machine
TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode- How remdesivir stalls the SARS-CoV-2 polymerase (Nat Comm)
- Movie of polymerase stalling (Nat Comm)
- Second mechanism of remdesivir inhibition (J Biol Chem)
- Watson Crick molecular model (Science Museum Group)
- Letters read on TWiV 819
- Timestamps by Jolene. Thanks!
Kathy – Great Lakes Science Center, Cleveland
Rich – How to Temporarily Disable Your Keyboard with a Keyboard Shortcut in Windows
Alan – How to Make a Slave and Other Essays by Jerald Walker
Vincent – A structure for deoxyribose nucleic acid
Steve – How the immune system actually works
Lise – Lise Meitner: A Life in Physics
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv