This Week in Virology

TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.


episode 830: A culture of resistance

TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Download TWiV 830 (67 MB .mp3, 112 min)
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Links for this episode
  • Spike protein inhibition of V(D)J recombination in vitro (Viruses)
  • Evolutionary predictability of SARS-CoV-2 (PLoS Path)
  • Letters read on TWiV 830
  • Timestamps by Jolene. Thanks!
Weekly Picks

Kathy – When do we get back to normal? Maybe now.
Rich – The Covid-19 Pandemic
Alan – Yaupon Brothers American tea
Vincent – Cracking the genetic code (and Niremberg’s account)

Listener Picks

Justin – Partisan vaccination
Lisa – The Red Flag

Intro music is by Ronald Jenkees

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 2021-11-18  2h8m