The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more – in surprising and unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators.
Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 – 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease.
Show notes and video
06:04 - Introduction
08:12 - Atherosclerosis
13:49 - Brain
16:07 - Circulating LPS and behavior
19:05 - Toll-like receptors and inflammation
24:00 - Factors that affect intestinal permeability
30:10 - Alcohol
32:07 - Gluten
35:21 - Butyrate and dietary fiber
37:48 - Dietary fat
42:21 - Biomarkers of intestinal permeability
43:11 - Omega-3 fatty acids
50:02 - Q&A
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Learn about the blood-brain barrier
Learn about intestinal permeability
Learn about toll-like receptors
Learn about cerebral small vessel disease
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